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DRIVING A >£1M ICER FOR ACCEPTABLE LEVELS FOR REIMBURSEMENT
- Supporting a product undergoing a NICE HST appraisal for a severe and debilitating rare disease across England and Wales
- Cost-effectiveness modelling developed by an external agency produced unacceptably high ICERs (>£1 million per QALY) for reimbursement
- FIECON were brought in with 3 months till submission deadline to reduce the ICER and lead the NICE process
- Undertook a model review that identified implementation errors increasing the ICER, and other structural and context deficiencies that meant the model was not demonstrating the product’s value
- Developed strategic recommendations for ways to robustly reduce the ICER
- Corrected implementation errors and conducted a complete re-analysis of the statistical modelling in the key areas identified, including: parametric modelling for mortality and treatment discontinuation, recalculating transition probabilities to highlight product effectiveness improved over time, compliance and carer disutility
- Proposed and supported a patient/carer survey and Delphi panel to re-parameterise key inputs in the model
- Submitted a robust, well-written, and strategically thought-out submission which allowed the product to demonstrate the potential to be cost-effective within the 3 month deadline
- Reduced ICER substantially to <£150k per QALY using robust methodology for the next Committee meeting, which allowed a commercial agreement to be made between the manufacturer and NICE
- Rolled out the NICE HEOR strategy as the Global HEOR strategy, implementing this across country launches in Central Europe, Eastern Europe and Canada
Our vision is to use economics for the good of humanity. We do this by making a positive difference in the lives of our people, our clients, and our society.
Our core values guide our day-to-day actions and make FIECON a great place to work.
LEARN, GROW, AND FLOURISH TOGETHER
DELIVER RESULTS AND DELIGHT CLIENTS
IMPROVE LIVES AND BUILD A BETTER WORLD
We support and encourage our people to give back to causes close to their hearts by matching any donations and offering 4 days of paid volunteering leave per year. We empower them to follow their passions and apply their expertise and skills to charitable causes. From community-based volunteering to collaborations with international NGOs – our people have contributed in uniquely diverse ways.
We have a long way to go to achieve our vision, but we are on the right path.